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Muscle Mature Wife ((LINK))



Objective: The biological role of the adrenal sex steroid precursors--DHEA and DHEA sulphate (DS) and their decline with ageing remains undefined. We observed previously that administration of a 50 daily dose of DHEA for 3 months to age-advanced men and women resulted in an elevation (10%) of serum levels of insulin-like growth factor-I (IGF-I) accompanied by improvement of self-reported physical and psychological well-being. These findings led us to assess the effect of a larger dose (100 mg) of DHEA for a longer duration (6 months) on circulating sex steroids, body composition (DEXA) and muscle strength (MedX).




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Measurements: Fasting early morning blood samples were obtained. Serum DHEA, DS, sex steroids, IGF-I, IGFBP-1, IGFBP-3, growth hormone binding protein (GHBP) levels and lipid profiles as well as body composition (by DEXA) and muscle strength (by MedX testing) were measured at baseline and after each treatment.


Results: Basal serum levels of DHEA, DS, androsternedione (A), testosterone (T) and dihydrotestosterone (DHT) were at or below the lower range of young adult levels. In both sexes, a 100 mg daily dose of DHEA restored serum DHEA levels to those of young adults and serum DS to levels at or slightly above the young adult range. Serum cortisol levels were unaltered, consequently the DS/cortisol ratio was increased to pubertal (10:1) levels. In women, but not in men, serum A, T and DHT were increased to levels above gender-specific young adult ranges. Basal SHBG levels were in the normal range for men and elevated in women, of whom 7 of 8 were on oestrogen replacement therapy. While on DHEA, serum SHBG levels declined with a greater (P


Conclusions: A daily oral 100 mg dose of DHEA for 6 months resulted in elevation of circulating DHEA and DS concentrations and the DS/cortisol ratio. Biotransformation to potent androgens near and slightly above the range of their younger counterparts occurred in women with no detectable change in men. Given this hormonal milieu, an increase in serum IGF-I levels was observed in both genders but dimorphic responses were evident in fat body mass and muscle strength in favour of men. These differences in response to DHEA administration may reflect a gender specific response to DHEA and/or the presence of confounding factor(s) in women such as oestrogen replacement therapy.


Skeletal muscle protein FSR during basal, postabsorptive conditions in pre- and postmenopausal women. Data are mean SEM. *, Value significantly different from value in premenopausal women (P


Skeletal muscle MYOD1, FST, MSTN, and FOXO3 gene expression (relative to GAPDH) during basal, postabsorptive conditions in pre- and postmenopausal women. Data are median (central horizontal line), 25th and 75th percentiles (box), and minimum and maximum values (vertical lines). *, Value significantly different from corresponding value in premenopausal women (P


Sex hormone treatment-induced changes in muscle MYOD1, FST, MSTN, and FOXO3 gene expression (relative to the average prepost change in the control group) in postmenopausal women. Data are median (central horizontal line), 25th and 75th percentiles (box), and minimum and maximum values (vertical lines). *, Significantly different from corresponding value in the control group (P


The mechanism(s) responsible for the progesterone-induced increase in muscle protein synthesis are unclear. However, our data suggest that the mechanism(s) responsible for the anabolic effect of progesterone is different from that of T and therefore most likely the result of progesterone receptor rather than androgen receptor activation, which is consistent with the results from studies performed on rodent cardiac muscle (53) demonstrating that blocking the progesterone receptor also blocks the stimulatory effect of progesterone on cardiac muscle protein synthesis. Progesterone treatment induced a significant increase in MYOD1 mRNA expression, whereas congruent with the results from studies conducted by other investigators (54, 55), T did not affect MYOD1 or MSTN mRNA expression. Increased progesterone-induced MYOD1 expression suggests increased satellite cell activation may play a role in this observation.


Strength training and building muscle can help you manage these newfound health risks and give you a sense of stability, strength, and independence. Building and maintaining muscle mass is especially important as you get older and can lead to physical and mental benefits.


You lose 5% to 8% of your lean muscle every 10 years after you pass 30 years old, and that percentage increases once you turn 60. Women over 50 need lean muscle to maintain muscle strength, bone strength, and to stabilize the joints, which can prevent injury.


Along with aiding with weight loss, bone density, and muscle mass, protein includes key nutrients such as collagen that enhances skin health. While young skin is firm, smooth and radiant, profound changes occur as you age. Collagen density decreases with age and is associated with a reduction in thickness. But when you eat protein-rich foods, your body is able to make more collagen by combining the amino acids you get from the protein. The reason most diets for active people should be high in protein is for lean muscle development or sustaining muscle. Metabolism increases with recovered muscles, and protein has a very low conversion rate to fat making it perfect for weight loss.


If you want to keep your metabolism high to avoid frailty as you age, aim for the recommended 0.8 grams of protein per kilogram (2.2 pounds) of body weight per day. Spreading your protein intake throughout the day will keep you satiated and will also help prevent the loss of muscle mass.


Protein is also essential not just for post-workout recovery but it also helps maintain muscle mass. Women going through menopause may see a decrease in muscle mass, so protein can help avoid this. Plus, bone mass density also declines thanks to the decline of the hormone estrogen; the correct amount of protein can aid bone health.


Transformation Protein Powder can help women over 40 find the right balance of protein and other key nutrients their bodies need. Transformation Protein contains a premium blend of egg white, collagen peptide and plant proteins along with all nine essential amino acids, MCT Oil, probiotics, and digestive enzymes. Its bioactive formula creates a biological response in your entire body to optimize your workout recovery and help keep your muscles strong.


NIA-supported researchers have been studying the effects of strength training for more than 40 years and have identified multiple ways it can benefit older adults, including maintaining muscle mass, improving mobility, and increasing the healthy years of life. Learn more below about these findings from NIA-supported researchers, along with their tips for maintaining strength or becoming stronger as we age.


Some people have a hard time gaining muscle no matter how much they lift, while others have a hard time losing weight even when focusing on aerobic activity. This variability from person to person is another area of current research both at NIA and the institutions it supports.


Derived from the Greek root words sarx (flesh) and penia (loss), sarcopenia is defined as a decline in muscle mass, strength, and function. It is often associated with older adults, but some forms of sarcopenia can also affect middle-aged people. Sarcopenia has been connected to weakness; fatigue; lower energy levels; and difficulty standing, walking, and climbing stairs. Sarcopenia is more likely to occur in people with chronic diseases and may contribute to risk of falls, fractures, other serious injuries, and premature mortality. Poor nutrition and lack of exercise can increase the odds of developing sarcopenia. If you or a family member is feeling general weakness, talk with a doctor. It could be related to sarcopenia or another medical condition.


NIA-supported scientist Roger A. Fielding, Ph.D., associate director of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University outside Boston, is a strong proponent of continuing to push our muscles as we age. He leads multiple studies aimed at better understanding age-related changes in muscle structure and function and how adding resistance training can prevent frailty and improve mobility and independence.


Strength training (also known as resistance training) is different than aerobic exercises such as running, cycling, or walking. Weightlifting, either with machines or free weights, is one type of resistance training. Other types include using medicine balls or resistance bands, or body weight-bearing exercises such as pushups, squats, or yoga. Resistance training requires our muscles to contract to lift a heavy object against the pull of gravity.


The more weight we contract against, the faster our bodies burn through reserves of adenosine triphosphate (ATP), a molecule that carries energy to cells. As we lift weights or do other demanding exercises, our ATP reserves are replenished through a complex, coordinated metabolic and chemical response that cascades through the entire body, including sparking short-term chemical changes in the DNA of muscle tissue that make them more tuned to specific proteins supporting sugar and fat metabolism. 041b061a72


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